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The expression of pro-ferroptosis genes was also found to be downregulated in the epidermis of mutant mice, and the expression of ferroptosis-suppressing genes such as Gpx4 and Slc7a11 was upregulated

It is estimated that about 30% of the global population is affected by nonalcoholic fatty liver disease

Glutathione, a tripeptide composed of three amino acidscysteine, glutamine, and glycinefunctions as the body's primary antioxidant, playing an essential role in various physiological processes

Tuo QZ, Liu Y, Xiang Z, Yan HF, Zou T, Shu Y, Ding XL, Zou JJ, Xu S, Tang F, Gong YQ, Li XL, Guo YJ, Zheng ZY, Deng AP, Yang ZZ, Li WJ, Zhang ST, Ayton S, Bush AI, Xu H, Dai L, Dong B, Lei P (2022) Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine metabolites AQ-QI and DEA-QI with glutathione

1 In particular, mitochondria play a central role in energy production and are considered a druggable target to counteract I/R injury