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The rd1 mouse is a common animal model used to study RP in which the expression of over 60 genes, related to proliferation, apoptosis, and transcription, is modified via a mutation in the phosphodiesterase-6 gene, which affects the metabolism of cyclic guanosine monophosphate

These metabolic pathways not only drive the progression of each disease independently but are also interconnected through shared biological mechanisms

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10.1038/aps.2017.28 13 ChenW.LiP.LiuY.YangY.YeX.ZhangF.et al (2018)

doi: 10.1182/bloodadvances.2020002177 118 TamuraKSaitoHAsakuraHOkamotoKTagawaJHayakawaTet al