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The combination according to the present invention can be prepared by mixing the active ingredients with suitable excipients for the formulation of pharmaceutical and/ or dietetic compositions which can be administered to human subjects or to animals

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Notably, inhibition of the depalmitoylation enzyme acylprotein thioesterase 2 led to delayed onset and lower rates of melanoma in mice expressing melanocytespecific zinc finger DHHCtype palmitoyltransferase 13 and an MC1R variant

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