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J Am Coll Cardiol

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PHYSICIAN-DEVELOPED, BUILT FOR MODERN WELLNESS: Created by Dr

doi: 10.1016/j.jphotobiol.2014.03.028

The rd1 mouse is a common animal model used to study RP in which the expression of over 60 genes, related to proliferation, apoptosis, and transcription, is modified via a mutation in the phosphodiesterase-6 gene, which affects the metabolism of cyclic guanosine monophosphate

But as we age, its level also decreases
