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Cellular Signaling Pathways: S-Glutathionylation is intricately woven into various cellular signaling pathways, influencing processes such as apoptosis, immune response, and cell proliferation

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[DOI] [PMC free article] [PubMed] [Google Scholar] Shosha H.M., Ebaid H.M., Toraih E.A., Abdelrazek H.M.A., Elrayess R.A

Sorafenib induces ferroptosis by targeting the cystine/glutamate anti-transport system Xc- [154,155,156,157], an effect that impinges on cystine uptake, thereby preventing subsequent synthesis of glutathione (GSH), the major intracellular antioxidant, preventing GPX4 activation [158, 159], and can trigger ER stress and ferroptosis