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Longer-term use also increased whole-body lean mass and improved stair-climbing performance in healthy older adults, despite stable quadriceps volume, suggesting functional neuromuscular adaptations rather than localized hypertrophy ( Supplementation alongside exercise enhanced both humoral and cellular responses to influenza vaccination, yielding greater antibody production, higher hemagglutination inhibition titers, and stronger expansion of nave and effector CD4 + T-cell subsets, with particularly pronounced benefits in sedentary participants (Monteiro et al., 2020)

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