benefits and side effects of glutathione for Skin: Benefits, Results, & Myths (2025 Guide) Gluathione: A Super Antioxidant -
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R., Bradley, M

Users stopping niacinamide typically experience very gradual benefit decline over 1-3 months without dramatic reversal, maintaining 40-60% of improvements long-term if treatment lasted 6+ months, and tolerating breaks or cycling without rebound effects or significant regression concerns

But honestly, thats not the right question to be asking

Mian P, Allegaert K, Conings S, et al

107, 23312336.10.1073/pnas.0913689107 33 MayM

2025;12(1):e2407284