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Ligand binding studies of lactam-bridged variants with the conformation-specific ligand Selective Active-Fit 1 ( SAFit1 ) revealed a 6-10-fold increase in binding affinity for the L1 and L2 variants, and a 39-fold improvement for the L3 analog, confirming the successful stabilization of the transient binding pocket

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doi: 10.1007/s10545-010-9242-z 5
In real cases, outcomes depend on several factors such as baseline skin condition, accompanying skincare practices like sun protection, and lifestyle habitsall of which influence visible changes
