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Importantly, Sod1-dependent genes fall into five categories that are involved in oxidative responses: oxidative stress, replication stress, DNA damage response, general stress response and Cu/Fe homeostasis (Fig

Based on these and other observations, it was proposed that cytosolic GGC, rather than vacuolar or extracellular GGT, is the major enzyme initiating GSH degradation and that this route could be particularly important in the intercellular transport function of GSH (Ohkamu-Ohtsu et al., 2008)

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We designated the state in which the NBDs are further apart as IFwide (Fig

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