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[19] identified ring finger protein 217 as a novel E3 ligase mediating the degradation of ferroportin (FPN), which controls iron output alone or together with hepcidin

In 2021, Yangs group reported alkyl-connected PROTAC 72 , targeting programmed cell death-ligand 1 (PD-L1) protein, as a novel cancer immunotherapy strategy 127

Indirectly, yes

[DOI] [PMC free article] [PubMed] [Google Scholar] 267.Zhang W.X., Wang H., Cui H.R., Guo W.B., Zhou F., Cai D.S., Xu B., Jia X.H., Huang X.M., Yang Y.Q., et al

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Nutrients 9 , 866