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(2015) investigated plasma AA profiles in children with CD and observed significantly elevated Asn levels compared to HCs (Sevinc et al

Clinic and pre-clinic studies showed decreased inflammatory biomarkers and disease improvement (Table 5) [8, 170, 171, 204211]

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Yu et al, 2012), including poor trial design, resistance because of mechanisms in addition to or other than P-glycoprotein, and failure to achieve adequate levels of the reversing agent in the tumor tissue