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The transgenic Col1a1 tm1jae (Col R ) mice have a mutation in the collagenase cleavage site of the 1 chain of collagen type I, and as a consequence of the reduced collagen turnover they accumulate collagen in various tissues

It shows a commitment to precision, and in the world of peptide research, precision is everything

[DOI] [PubMed] [Google Scholar] 113.Cuadrado-Tejedor M., Hervias I., Ricobaraza A., Puerta E., Prez-Roldn J., Garca-Barroso C., Franco R., Aguirre N., Garca-Osta A

These findings support 16 weeks as the minimum required period to attain peak improvement in rolling scars and initiate a response in ice pick scars

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However, it provided a scaffold which was hoped to be a universal template for homology modeling and drug design for other GPCRs a notion that proved to be too optimistic