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Additionally, the location and size of the infarct can affect the efficacy of ferroptosis inhibitors, as different brain regions may have varying sensitivities to iron overload and oxidative stress (Bishop et al

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For this study the seo1 met15 ecm38 dug3-2 strain, that is deficient in -Glu-Met degradation (as described above), was used

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Once inside the cell, the acetyl group is removed, releasing active glutathione where its needed most

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