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To determine differences between groups, we performed a post hoc pair-wise (TukeyKramer) comparison

Chronic Inflammation: The ongoing autoimmune attack and gut dysfunction create a state of chronic, low-grade inflammation

Formation of the NFT radical anion by cellular reductases To elucidate the mechanism of Nrf2 activation by NFT, we focused on the ability of NFT to yield an activated species capable of oxidizing critical sulfhydryl groups in the Nrf2-Keap1 complex

It has been found that smooth muscle cells in COPD patients exhibit mitochondrial dysfunction, which in turn causes an increase in mitochondrial ROS, resulting in an oxidative-oxidative imbalance that contributes to the development and progression of COPD

Kurko et al., 2014)