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Studies indicate that elevated levels of metals such as Fe, Cu, Mn, and Zn can damage the UPS and are associated with OS, mitochondrial dysfunction, and protein misfolding [63]

We refer readers to the FY 2023 IPPS/LTCH PPS final rule (87 FR 49263 through 49267), which describe the same updates we are proposing to apply to the THA/TKA Complication measure in the Hospital VBP Program, including updates to the risk adjustment and measure calculations

In its RNA interference (RNAi) transgenic lines, a significant increase in the transcription level for the lycopene beta cyclase 2 ( SlLCY-b2 ) gene was detected, which encoded a key enzyme located at the downstream branch of the carotenoid biosynthetic pathway

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These findings suggest that esterifying PQQ could be a promising strategy for developing novel amyloid inhibitors based on PQQ (Tsukakoshi et al., 2018)