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doi: 10.1074/jbc.274.18.12675 13

We included each participants body temperature time-of-day variables (average B1 and B2) in adjusted models to hold constant the average effect of time of day for each participants average body temperature

Primary research: Neuroprotection, cellular survival, age-related cognitive decline Mechanism: Activates STAT3 signaling, inhibits Bax-mediated apoptosis, and interacts with IGFBP-3 Regulatory status: Not FDA-approved

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Science 368 , eaba2412 (2020)

Everything below documents the once-weekly research/trial protocol under a strict research-use-only framing, with the reconstitution arithmetic shown so the numbers are auditable