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Discuss supplementation with a health professional beforehand if you have diabetes or a cardiac condition

The promoters of BNIP3 and NIX both include functional HIF-1-responsive elements (HREs) and are elevated by hypoxia, indicating their possible roles in hypoxia-induced apoptosis [142,143,144]

10.1371/journal.pbio.1000614 351 SwarupV.PhaneufD.DupreN.PetriS.StrongM.KrizJ.et al

Although current clinical data supporting its effectiveness remain limited, there is a clear need for future randomized trials to reinforce the evidence base and identify which patient subgroups may derive the greatest benefit [156]

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A significant threefold increase in 8-OHdG was observed only for mtDNA isolated from parietal lobe of AD, whereas no differences were evidenced in levels of 8-OHdG in nDNA from AD subjects (431)