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Nature (2010) 467(7317):8328.10.1038/nature09410 280 AhlgrenMMelbyeMWohlfahrtJSorensenTIA

There were no major side effects that led to withdrawal from the clinical trial prior to the last assessment

Wang L., Yin Z., Wang F., et al., Hydrogen Exerts Neuroprotection by Activation of the miR21/PI3K/AKT/GSK3beta Pathway in an in Vitro Model of Traumatic Brain Injury, Journal of Cellular and Molecular Medicine 24, no

Seeing rapid initial results reinforces medication-taking behavior, while slow or modest results can lead to discontinuation before maximum benefit is achieved

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