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Acknowledgements We thank Nicole Barucci, Lori Lopresti-Morrow, and George Mourgkos from ATP R&D for supporting the in vivo studies, Elizabeth Elliot for her operational support at Aethon Therapeutics and assistance with manuscript submission, and William Rice, Bing Wang, and Huihui Kuang from the NYU Langone Healths CryoElectron Microscopy Laboratory (RRID: SCR_019202)

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