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47 These tests can be used to assess baseline status, risk of complications, and response to treatment

In this regard, it can be noted that transcription of the gdhA gene initiates from two promoters, one weak, constitutively expressed, called gdhA P1, and another, more potent, called gdhA P2, transactivated by GdhR, a transcriptional regulator whose DNA binding is inhibited by -ketoglutarate (Pagliarulo et al., 2004)

Meantime, DDCu was reduced to Cu + by cellular glutathione to react with lipoylated proteins of the tricarboxylic acid cycle and destabilize the FeS cluster proteins, leading to the aggregation of dihydrolipoamide S-acetyltransferase and cuproptosis in cancer cells

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But some plant GSTs show activity on ITCs in vitro 37,38,39 , and exogenous application of AITC upregulates transcript levels of GST s and depletes glutathione 17,40,41

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