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They are not interchangeable, though

Lepidium sativum (LS), a member of the Brassicaceae family, is an edible annual herb that is grown in Arabia, Europe, India, and the United States

The absence of serine hydroxymethyltransferase 2 (SHMT2) increases circulating glycine levels but reduces hepatic methylation potential, thereby enhancing susceptibility to hepatic steatosis [64]

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84 The initial hypothesis that inducible nitric oxide synthase (iNOS) in Kupffer cells is a significant source of NO formation 85 was quickly dismissed, as iNOS was not consistently induced in different models 86 and iNOS inhibitors did not provide protection

Nanomed J