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Role of presenilin in mitochondrial oxidative stress and neurodegeneration in Caenorhabditis elegans

The results demonstrated that TSA concentration-dependently enhanced IKs current amplitude (EC50=64.5 M), accelerated channel activation kinetics, slowed inactivation and shifted the voltage dependence of IKs activation toward hyperpolarization (134)

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Estimates of the relative contributions of heritability and environmental factors are influenced by varying assumptions of autism prevalence, among other factors, and more research is needed to generate more precise estimates