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Human cytochrome P450 enzyme: a status report summarizing their reactions, substrates, induction, and inhibitors

There are both severe and mild SCD genotypes, which reflect the type of symptoms and prognoses for the disease

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Tumors undergoing lipid oxidative stress release immunogenic cell death signals such as high mobility group box 1 (HMGB1), a mechanism critical for GPX4-mediated tumor targeting [50]

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1 Moreover, the high failure rate of clinical trials makes it difficult to effectively validate hypotheses, possibly attributed to the coexistence of multiple theories (which will be detailed in subsequent sections)