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An alternative solution to ECM remodeling seems therefore necessary, through mechanisms that reuse existing molecules, rather than relying on de novo synthesis

doi: 10.1155/2022/7410865 174 ZengMZhouHHeYDuHYinJHouYet al

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Then, they have validated key findings in vitro and in vivo in Cftr -KO mice and ex vivo in CF patient-derived endothelial cells