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identified the first covalent NNMT inhibitor 6 that reacts with a non-catalytic cysteine residue (C165) in the active site of NNMT to label NNMT in cell lysates
NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability
Nat Chem Biol
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