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Strong: At least one high-quality double-blind, randomised sham-controlled trial demonstrates clinically meaningful benefits, supported by a consistent systematic review/meta-analysis and robust mechanistic evidence

Erchen Decoction (ECD), originating from the Taiping Huimin Heji Jufang (Formulary of the Peaceful Benevolent Dispensary) compiled by Chen Shiwen during the Song Dynasty, is composed of Juhong ( Citrus reticulata 'Chachi' Blanco), Banxia ( Pinellia ternata (Thunb.) Breitenb), Fuling ( Poria cocos (Schw.) Wolf), Gancao ( Glycyrrhiza uralensis Fisch

Double-layer hydrogel with glucose-activated two-stage ROS regulating properties for programmed diabetic wound healing

Here we show that biologically relevant S 0 species are potent radical scavengers and chain terminators, in vitro and inside living cells, and are important for the protection of membranes against LPO and, thus, are also relevant to ferroptosis sensitivity

However, these approaches face critical delivery challenges, including poor tumor penetration, rapid systemic clearance, and off-target toxicity, necessitating nanomaterials-mediated targeted delivery systems to achieve tumor-specific accumulation and enhanced therapeutic precision

Clinical studies have generally shown good tolerance at recommended doses, with most adverse effects being mild and transient