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The glycerol phosphate shuttle is coupled to an inner mitochondrial membrane, FAD-linked dehydrogenase, of low energy potential like that found associated with Complex II

Even though it is found in many foods, a Vitamin B12 deficiency is still relatively common

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It inhibits lipogenesis (the formation of new fat from non-fat substrates) meaning fewer calories may be converted into stored fat

Anecdotal reports from research subjects and biohacking communities describe body composition improvements, increased subjective energy and mental clarity, and minimal side effects, though these uncontrolled observations require cautious interpretation and cannot substitute for rigorous clinical trials