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Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors

Neurology 58, 15441546

In: StatPearls [Internet]

[DOI] [PubMed] [Google Scholar] 106.Esposito C., Ugo Garzarella E., Santarcangelo C., Di Minno A., Dacrema M., Sacchi R., Piccinocchi G., Piccinocchi R., Daglia M

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It activates the Keap1/P62/Nrf2/ARE signaling pathway, upregulates antioxidant enzymes such as HO-1 and NQO1, and enhances intracellular glutathione (GSH) and NQO1 levels (50)