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[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Pardridge WM

Furthermore, progressive loss of NRF2 activity was seen with aging, which may be explained by studies showing that the expression of NRF2 positive regulators P62 and BRCA1 decreased with age, while NRF2 negative regulators, KEAP1 and BACH1, increased with age [113]

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As shown by some genetically engineered purple tomatoes, anthocyanins can also be synthesized in the pulp of the fruit, provided the biosynthetic pathway is appropriately activated