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Sex steroids regulate the fish responsiveness to both GH stimulators and inhibitors (46, 47), and it is expected that the responsiveness of fish somatotrophs to hypothalamic factors follows a seasonal pattern associated with the sexual and gonadal maturation typical of each species

There was no statistically significant difference in the frequency of side effects between groups (logRR=0.36

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This implies that while bridge node rankings remain relatively consistent, they should be interpreted with some caution

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Importantly, these effects occur without activation of growth hormone receptor pathways or alteration of IGF-1 signaling, allowing AOD 9604 to be used as a tool for isolating metabolic signaling mechanisms