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Future research should prioritize expanding sample sizes with longitudinal sampling to validate candidate biomarkers, performing functional validation through in vitro and in vivo models, conducting multi-tissue comparative analyses to elucidate systemic selenoprotein networks, integrating metabolomic and lipidomic datasets for comprehensive metabolic profiling, and exploring translational potential of GPX1, SELENOW, and other candidates as minimally invasive blood biomarkers for monitoring selenium status in high-altitude livestock production

Photodynamic therapy, a systemic treatment used in oncology to eradicate early-stage cancer and reduce the tumor size in end-stage cancers, has also been used to treat wet AMD (Wormald 2007)

It is reported that hypoxic stress significantly elevated hepatocyte apoptosis in both Carassius gibelio (Wu et al., 2022a) and Pelteobagrus vachelli (Zheng et al., 2021)

Even supplements labeled as safe can be harmful in high doses

doi: 10.1016/j.neuroscience.2019.01.024

The primary antibodies included -actin (Sigma-Aldrich, A5316), lamin B1 (HUABIO Antibodies, ET1606-27), HIF-1 (Abcam, ab228649), HIF-2 (Novus, NB100-122), Acer2 (PA5-39016), PP2A (Invitrogen, MA5-32920), p-PP2A (Invitrogen, MA5-32158), -syn (BD, 8249518), and p--syn (Abcam, ab51253)