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Overall, -Arr-dependent signaling has been demonstrated most thoroughly for the mitogen activated protein kinases (MAPK) cascades: ERK, c-Jun amino-terminal kinase, p38 (Burghi et al., 2021

The combination can significantly improve your results

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the liver being the most prominent place of accumulation, as we have already seen)

For example, engineered Escherichia coli Nissle 1917 (EcN) co-expressing anti-PD-L1 and anti-CD9 nanobodies (EcN-Nb) and modified with ICG-loaded zinc-based MOFs to generate EcN-Nb-ZIF-8CHO-ICG (ENZC), can specifically release nanobodies in response to NIR radiation thereby targeting tumor-derived exosomes (TDEs) to alleviate immunosuppression, such as reshaping TAMs to the M1 state and activating more effective and cytotoxic T lymphocytes, ultimately inhibiting tumor proliferation and metastasis (229)