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Table 1 provides the summary of the tissue biomarkers as given below: TABLE 1 Tissue based biomarkers in OSF diagnosis

10.1002/ajmg.b.32421 28 KomatsuM.WaguriS.UenoT.IwataJ.MurataS.TanidaI.et al

Statistical analysis showed that urinary cortisol levels throughout the day showed a different pattern between the control and test day (interaction term of sampling time and treatment: 2 = 6.00, df = 1, P = 0.01) (Table 2)

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Its chemical structure is 1,7-bis (4-hydroxy-3-methoxyphenyl) 1,6-heptadiene-3,5-dione (Figure 1), which has anti-inflammatory, anti-oxidation, anti-virus, anti-infection, anti-tumor and other biological activities (Lestari and Indrayanto, 2014)