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Bcl2-family death agonists induce OMM permeabilization, thereby promoting cytochrome c release, whereas Bcl2-family death antagonists prevent it

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Key measurements include lipid peroxidation markers such as malondialdehyde and 4-hydroxynonenal, antioxidant defense markers such as GPX4 activity and the GSH/oxidized GSH ratio and advanced MRI-based assessments such as quantitative susceptibility mapping to quantify brain iron deposition (95,96)

Liver health Antioxidant deficiencyincluding a lack of glutathionecan exacerbate cell death in the liver and lead to fatty liver disease

doi: 10.1016/j.freeradbiomed.2018.05.001 87 MyungSKLeeCWLeeJKimJKimHS

Y., DePinho, R