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GSEA also revealed significant inhibition of cellular functions related to infection, the immune response and carcinogenesis, such as the B-cell receptor signaling pathway, natural killer cell-mediated cytotoxicity, Yersinia infection, PI3K-Akt signaling pathway, and proteoglycans in cancer

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Since either other lipoxygenases or non-enzymatic autooxidative mechanisms may compensate for the loss of Alox15 , we asked whether ablation of Gpx4 in the hematopoietic system would result in the perturbation of reticulocyte maturation

In addition, both vitamin C and E improved pregnancy rates, but the quality of this evidence was low

Celastrol (Cel), a natural triterpenoid compound [212], can increase the production of reactive oxygen species (ROS), disrupt mitochondrial membrane potential, promote mitochondrial fission, and further activate ATG5/ ATG7-dependent autophagy, and inhibit tumor growth in vivo when combined with erastin [213]