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By restraining NRF2 activity, GSH synthesis facilitates the expression of lipogenic enzymes and enables the supply of triglycerides into circulation

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Cardiovascular effects beyond cardiac hypertrophy are poorly characterized for IGF-1 DES specifically, though IGF-1 influences cardiovascular physiology through effects on vascular smooth muscle, endothelial function, blood pressure regulation, and cardiac contractility - chronic perturbation of these processes carries unknown risks

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Allocati N, Masulli M, Di Ilio C, Federici L (2018) Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases