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These findings collectively demonstrate that EC metabolism involves a coordinated sequence of intestinal absorption, hepatic and colonic biotransformation, and renal elimination, with distinct phase II conjugates acting as clearance intermediates and serving as characteristic metabolic signatures of EC exposure (Figure 3)

This work is supported by Young Scientist grant by Indian National Science Academy (INSA/SP/YSP/152/2018/232), DST-FIST Program (No

doi: 10.1016/j.toxlet.2020.08.006 53 ImDUKimSCChauGCUmSH

In Bacillus megaterium CbiX L , the catalytically important histidine residues are found in the N-terminal domain of the protein (His14 and His79) indicating that this protein has evolved from a fusion of two CbiX S in a different way to CbiK