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doi: 10.1016/S0005-2736(97)00097-7

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Rad4 recognizes the local destabilization of the DNA duplex, which is common to many structurally unrelated DNA lesions, and thus explains the ability of Rad4 and XPC to detect a myriad of lesions

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For most healthy adults without a documented B12 deficiency, there is usually no medical benefit to receiving routine B12 injections , and they are unlikely to boost energy in the absence of deficiency