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Studies have shown that significant gut microbiota dysbiosis in OA patients modulates key lipid metabolites, contributing to OA progression

Oncogene 38, 22232240

Gu M, Iravani MM, Cooper JM, King D, Jenner P, Schapira AH (2004) Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms

Compounding gastrointestinal effects (severe nausea, vomiting, diarrhea, dehydration), unpredictable drug-drug interactions, and a complete absence of safety data

10.1016/j.mehy.2006.02.040 Med

In nrf2a5 homozygous mutants, the expression of tsh- was greatly increased compared with their WT siblings (Fig 2S, second from the left), consistent with the known effects of a lack of T.H