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Several studies have reported a significant negative correlation between HbA1c and serum zinc levels in individuals with diabetes

[DOI] [PMC free article] [PubMed] [Google Scholar] 179.Wang X., Zhu S., Pei Z., Drozda M., Stavrovskaya I.G., Del Signore S.J., Cormier K., Shimony E.M., Wang H., Ferrante R.J., et al

This makes Long R3IGF-I significantly more potent (2-3x) than IGF 1 LR3 in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins, and consequently more potential activity in the body

Therefore, while systemic fasting alone might not uniformly starve a tumor of monosaccharides, it could create localized nutrient shortfalls in parts of the tumor, potentially slowing progression in those microregions even if the overall tumor maintains sufficient glucose supply