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The association between glutamatergic metabolites and cognitive domains over two years Dorsal ACC Attention There was a significant different trajectory of the association between glutamate levels and RVP A score over the two years in FEP and HCs (group*time*RVP A score: p = 0.026) due to a positive association between glutamate levels and RVP A score over the two years in the FEP group (Table 3) but not in the HCs (main effect: p = 0.41)

Although almost all tissues in the body have some ability to metabolize chemicals, smooth endoplasmic reticulum in the liver is the principal "metabolic clearing house" for both endogenous chemicals (e.g., cholesterol, steroid hormones, fatty acids, proteins) and exogenous substances (e.g., drugs, alcohol)

Since their respective influence may vary widely between individuals, the establishment of well-defined normal ranges is necessary, which requires adequate numbers of normal individuals, in order for IGF-I measurements to have maximum utility