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it may simply mean more breakdown signal without proportionally more synthesis

In HCC cell lines, upon sorafenib administration, p62 inhibited Nrf2 degradation and enhanced its nuclear accumulation

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death

Journal of clinical gastroenterology, 53 (10), e416-e423

A few more well-studied factors stand out

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