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In a diseased state, TDP-43 is found mislocalized from the nucleus and aggregated in the cytoplasm of neurons within the central nervous system (CNS) in ~ 97% and ~ 45% of ALS and FTD cases, respectively [3, 4]

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This classification is determined by the FDA's evaluation of the facility's adherence to Current Good Manufacturing Practice (CGMP) regulations, taking into account the evidence gathered during the inspection and the company's subsequent response to any identified observations

doi: 10.3109/01612840.2011.569846 [DOI] [PubMed] [Google Scholar] 17.Australian Institute of Health and Welfare

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