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M., Cobley, J

[DOI] [PMC free article] [PubMed] [Google Scholar] Yamada Y

M.KouretasD.VeskoukisA.et al (2019b)

Abstract Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play pivotal roles in various physiological processes

As for the more general TKIs the sequence homology between IGF-1R and IR-A/B kinase domains presented a major problem and therefore side effects were of great concern ( The IGF-signalling system has long been an area of therapeutic interest in the treatment of breast cancer which was further supported by the findings of both the European Prospective Investigation into Cancer and Nutrition (clinicaltrials.gov database

Among all the complexes, promising in vitro antitumor activity was found for Pt(IV) complexes based on the cisplatin scaffold, bearing one axial indole carboxylate and one axial hydroxido ligand ( 1A and 1P )