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Description
Rare but serious risks include pancreatitis, gallbladder problems, and thyroid C-cell tumors (observed in animal studies, clinical significance in humans unclear)

And that is by, uh, a couple of mechanisms

Lipid peroxidation was lower only for the 9/4.5 mg IBU dose

16 (5), e2006203

J Neurol Sci 125(1):310

Collectively, these distinct routes of toxicity are not mutually exclusive and may act in parallel to induce cellular dysfunction
