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Lowering homocysteine with high dose B vitamins is effective in slowing cognitive decline and brain atrophy (56, 57), though this effect is dependent on baseline homocysteine concentrations

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Our study found 25 M luteolin had no significant effect on platelet aggregation induced by 3 M U46619, but 100 M luteolin significantly inhibited platelet aggregation induced by U46619

doi: 10.1080/15548627.2019.1687985 69 ChenXComishPBTangDKangR

Start with a high dose: Treatment for acute vitamin B12 deficiency often begins with higher doses (e.g., 1,0005,000 mcg per day)

Diabetes 61 , 197207 (2012)