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Indole-3-carbinol (I3C) and its metabolite DIM exert hormone-modulatory effects by shifting estrogen metabolism from the genotoxic 16-hydroxyestrone pathway toward the less carcinogenic 2-hydroxyestrone pathway, enhancing CYP1A1/1A2 activity, and simultaneously downregulating ER and upregulating ER expression, which together lead to suppression of estrogen-driven proliferation and sensitization of tumours to endocrine therapies (191)

[DOI] [PubMed] [Google Scholar] 274.Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL

PMID 12804452

Carnitine can be a useful tool to support this process, but it does not replace a healthy and balanced lifestyle

PubMed Central , Archives of Medical Research , vol

Childrens Hospital of Philidelphia