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Two important recent examples are the knockouts of the matricellular proteins thrombospondin-2 (TSP2) (35) and SPARC (secreted protein acidic and rich in cysteine) (36)

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elegans [1, 2], Drosophila [3, 4], and mice [6, 7]

The gsr-1 gene is vital in the stress response against several oxidants including juglone, cumene hydroperoxide, diamide, tert -butyl hydroperoxide and paraquat [57,79,82,83]

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