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There is a theoretical concern, supported by some biological evidence, that elevated IGF-1 activity in a patient with occult or a history of certain hormone-sensitive cancers could be problematic

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[DOI] [PubMed] [Google Scholar] Orlando RC, Hernandez DE, Prange AJ Jr, Jr, Nemeroff CB

Studies have shown that saphenous vein of humans and animals exhibits an active myogenic response with vasoconstriction when subjected to increased intraluminal pressure [72, 73]

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