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Proteomic analyses revealed that NNMT inhibition uniquely upregulated proteins involved in translation initiation, ribosomal biogenesis, and inflammatory regulation during muscle regeneration, suggesting multiple complementary mechanisms supporting muscle function
Mitophagy, the selective autophagic clearance of mitochondria, serves a key inhibitory role against ferroptosis (44)
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Over time, these crystals trigger gout flare-ups or gout attacks, leading to intense pain, redness, and swelling
